CIRCULATING TUMOUR CELLS

Circulating tumour cell (CTC) testing

An evidence-aware overview of CTC analysis and its limitations in medical decision-making.

What is a CTC test?

CTCs are tumour-derived cells shed into the bloodstream from a primary or metastatic site. Detection and enumeration are used in research and selected clinical contexts, but a CTC result alone cannot establish whether cancer is present, where it began or whether it has recurred.

A woman consulting a physician about the purpose and limits of CTC testing
A woman receiving a physician explanation before CTC testing

ABOUT THE INFORMATION

Research context and service information

CTC research findings and the information available from an individual test should be considered separately.

01

CURRENT POSITION

Current clinical position

CTCs are studied as a form of liquid biopsy, including associations with prognosis in some advanced cancers. Important gaps remain for population screening, method standardisation and proof that CTC-directed treatment changes improve outcomes.

CTC analysis does not replace recommended cancer screening, imaging, pathology or medical examination.
02

PROCESS

Typical process

  • Medical consultation to review health status, purpose and limitations
  • Collection of the required blood sample and shipment to the laboratory
  • Confirmation of the result method and expected timing when applying
  • Standard follow-up testing when clinically appropriate
03

LIMITATIONS

Important limitations

  • A non-detected result cannot exclude cancer.
  • Detection alone cannot establish malignancy or a primary site.
  • Results may differ by platform, marker set and threshold.
  • Blood collection has usual risks such as pain and bruising.
04

PUBLICATION

Reference publication

A pilot study of a microfluidic device in gynaecologic cancer is presented as background material for CTC research. Its applicability depends on the population, method and intended use.

Know who handles each step before choosing a test.

SGH provides pre-collection sales and general information to help people access overseas testing through Japanese medical providers. You can decide whether to proceed after speaking with your doctor.

SGH | Before blood collection

Information about plans, listed prices, the process and your preferred area. SGH does not provide medical care, genetic counselling or interpretation of results.

Japanese provider | Medical care

The provider handles eligibility, medical explanation, consent, blood collection and results. Ask your provider about genetic counselling and referral to a specialist when needed.

Taiwan laboratory | Testing

Specimens collected in Japan are sent to Taiwan. Confirm the test method, scope and reporting conditions in the test-specific documents checked by your medical provider before proceeding.

Read about the laboratory and responsibilities

FAQ

Frequently asked questions

Can CTC testing alone detect early cancer?

Current evidence does not support treating CTC analysis as a stand-alone general cancer screening test. Use age- and risk-appropriate standard screening.

Does an undetected result mean I do not have cancer?

No. CTCs are rare and detection depends on sampling and method. A non-detected result cannot exclude cancer.

CONSULTATION

Information for medical providers

Confirm the platform, intended use, cost, report format and clinical responsibilities before considering implementation.